Do not take LYOSAN:

• if you are allergic (hypersensitive) to losartan or to any other component
• if you have severe hepatic impairment is not recommended concomitant administration of nimodipine orally and antiepileptics.
• if you are, you think or plan to become pregnant (see also "Pregnancy and lactation")
• if you are breast-feeding
• if you have diabetes or impaired kidney function and you are treated with a drug that lowers blood pressure and containing aliskiren.

Take special care with LYOSAN:
It is important to tell your doctor before taking LYOSAN

• if you have a history of swelling of the face, lips, throat and / or tongue, if you suffer from excessive vomiting or diarrhea leading to an extreme loss of fluid and / or salt in your body.
• if you receive diuretics (medicines that increase the amount of water excreted through the kidneys) or are on a diet to reduce the salt, which leads to great loss of fluid and salt from your body.
• if you have a narrowing or blockage of the blood vessels that lead to the kidneys or recently have had a kidney transplant.
• if you have heart failure with or without renal impairment or life-threatening cardiac arrhythmias. Particular care is required when a beta blocker is also administered.
• if you have problems with the heart valves or the heart muscles.
• if you suffer from coronary heart disease (caused by a reduced blood flow in the blood vessels of the heart) or cerebrovascular disease (caused by decreased blood flow to the brain).
• if you have had gout.
• if you suffer from primary hyperaldosteronism (a syndrome associated with increased secretion of the hormone aldosterone by the adrenal gland, caused by an abnormality within the gland).
• if you are taking, any of the following medicines used to treat high blood pressure:
• an ACE inhibitor (for example enalapril, lisinopril, ramipril), especially if you have kidney problems related to diabetes.
• alisikren

Your doctor may check your kidney function, your blood pressure and the amount of electrolytes (eg potassium) in your blood at regular intervals.

Taking / using other medicines:
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines. including medicines obtained without a prescription or herbal medicines and natural products. In particular, pay attention if you are taking any of the following drugs when you are treated with LYOSAN:

• other medicines that lower blood pressure because they may further reduce blood pressure. Blood pressure can also be reduced by the following drugs: tricyclic antidepressants, antipsychotics, baclofen, amifostine
• drugs that maintain or may increase potassium levels (eg potassium supplements, potassium-containing salt substitutes or medicines which retain potassium. such as certain diuretics (amiloride, triamterene, spironolactone or heparin)
• nonsteroidal antiinflammatory drugs such as indomethacin, including cox 2- inhibitors (drugs that reduce inflammation, and are used in pain relief), because it can reduce the effect of losartan pressure reduction
• If you have kidney dysfunction, concomitant administration of these drugs can lead to worsening of renal function
• Lithium containing medicines should not be taken in combination with losartan without close supervision by your doctor. It is likely to require specific precautionary measures (eg blood tests)
• Your doctor may need to change the dose of these other medicines or take other precautions
• If you are taking an ACE-inhibitor or aliskiren

Taking LYOSAN with food and drink:
The LYOSAN can be taken with or without food.

Pregnancy and breast-feeding:
It would be better to not take losartan in the first 12 weeks of pregnancy and should not take them at all after the 13th week as their use during pregnancy may be harmful to the baby. If you become pregnant while on losartan, tell your doctor immediately. A switch to a suitable alternative treatment can be selected in advance of a planned pregnancy. You should not take losartan if you are breast feeding. Consult your doctor or pharmacist before taking any medicine.
Use in children and adolescents:
Losartan has been studied in children. For more information, contact your doctor.

Driving and using machines:
No studies on the effects on the ability to drive and use machines. LYOSAN is not likely to affect the ability to drive and use machines. However, as with many other medicines used to treat high blood pressure, losartan may cause some people feel dizzy or drowsy. If you experience dizziness or drowsiness should contact your doctor before attempting such activities.

Important information about some of the ingredients of LYOSAN:
LYOSAN contains lactose monohydrate. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.

What's in LYOSAN:
The active substance is losartan potassium.
Each tablet LYOSAN 50 mg containing 50 mg losartan potassium.
Κάθε δισκίο LYOSAN 100 mg περιέχει 100 mg losartan potassium.

The other ingredients are: microcrystalline cellulose, lactose monohydrate, sodium starch glycolate and magnesium stearate.
Coating: hypromellose 6 cps, macrogol 400, titanium dioxide Cl 77891 E171,iron oxide yellow Cl77492 E172,yellow lake No.6 E110, Lactose Monohydrate